Stratified medicine aims to identify groups and subgroups of patients with distinct characteristics that that may determine disease subclasses, susceptibility and also responses to treatments and other interventions. Ultimately stratified medicine seeks to ensure that the right patient gets the right treatment at the right time.
Systems medicine takes a holistic view of all the distinct systems and processes of the human body integrating biochemical, physiological and environmental interactions with clinical features in order to provide new information to inform patient stratification.
Imperial College is at the forefront of stratified and systems medicine approaches. It hosts the MRC-NIHR National Phenome Centre, a resource for metabolic phenotyping that uses techniques pioneered by AHSC researchers to measure an individuall’s chemical profile reflecting their genes, environment and lifestyle.
Alongside this the Imperial BRC Institute for Translational Medicine and Therapeutics brings together AHSC capabilities in health informatics, genetics, imaging, cellular and molecular analytical technologies, allowing researchers to acquire and interrogate a wealth of biological information at an individual and population level.
In terms of education the Imperial STRATiGRAD PhD programme is training the next generation of scientists able to work at the interface of different analytical disciplines to drive new discoveries at the systems level.
AHSC research programmes in stratified and systems medicine cover a wide range of conditions including cancer, liver and GI diseases, diabetes, and cardiovascular disease. Working with expert clinicians and patients using this approach will enable us to improve patient safety, enhance patient experience through more targeted, effective treatments and reduce healthcare costs through use of fewer ineffective interventions.